The image of different modes, such as CTA and MR of this example (middle of the graph), is registered and fused. The shape and internal components of the plaque are segmented by taking advantages of different modes, and the 3D geometric structure of lesions is reconstructed based on the segmented results (left side of the graph). In vivo, blood vessels and lesions are affected by blood pressure and are in a dilated state. Therefore, it is necessary to obtain the geometry of blood vessels and lesions under zero pressure by solving the inverse problem. Finally, the mechanical loads in the plaque structure are calculated by Fluid-Solid Interaction Analysis, taking into account the effects of blood pressure and blood flow, in order to evaluate the risk of plaque rupture.
[Zhongzhao Teng, Jing He, Umar Sadat, John R Mercer, Xiaoyan Wang, Nasim S Bahaei, Owen M Thomas, Jonathan H Gillard, IEEE Transactions on Biomedical Engineering, 2014, 61(1): 35-40]